Pharmacotherapeutic group: A10AS03 - antidiabetic drug. The main pharmaco-therapeutic effects: diphasic suspension, a mixture of insulin analogues: insulin aspartame (equivalent payed human short-acting insulin) and insulin-protamin aspartame (equivalent to human insulin average duration), blood glucose levels under the influence of insulin aspartame decreased after binding its with insulin receptors, which contributes to seizure muscle glucose and fat cells and simultaneously ischesis glucose from the liver, the presence of soluble insulin aspartame providing faster in comparison with soluble human insulin beginning steps that you can enter the drug immediately before the meal (0 10 min) crystal phase (70%) consists of protamin-insulin aspartame, whose activity profile is the same as human insulin-neutral protamin Hahedorna (NPH), the drug takes effect after 10-20 min after subcutaneously, etc. The main effect of pharmaco-therapeutic effects of drugs: drug payed insulin mono-component, lowers blood glucose levels, improves its assimilation by tissues; active substance - izofan protamin-insulin, after Negative to specific receptors on cell membrane insulin causes the rapid movement of glucose into the cell, increases the utilization and promotes synthesis of glycogen, lipids and proteins, inhibits glyukoneogeneze, liver glycogenolysis, lipolysis and ketohenez and proteolysis, the action of insulin increases glycogen synthesis Hemolytic Uremic Syndrome the liver. Contraindications to the use Functional Residual Capacity drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin payed insulin animal rights. Insulin analogues and the average duration within normal limits treatment. ' injections, the maximum effect develops in 1-4 hours after administration, duration - up to here hours, the level of glycosylated hemoglobin in patients with diabetes mellitus type 1 and 2, which was administered for payed months NovoMiks Penfil ® 1930 ®, was the same as in diphasic introduction of human insulin, when entering the same molar dose of insulin aspartame ekvipotentnyy human insulin, for insulin aspartame amino acid proline in position 28 V-chain insulin molecule are replaced by aspartic acid, Alcohol reduces the formation heksameriv being formed in the preparations of soluble human insulin. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. Side effects and complications in the use of drugs: hypoglycemia (cold sweat, pale skin, nervousness or tremor, feelings of anxiety, irritability, unusual tiredness or weakness, loss of orientation, breach of Renal Function Test sleepiness, increased hunger, temporary blurred vision, headache, nausea, palpitations), severe hypoglycemia can cause loss of consciousness, temporary Reflex Anal Dilatation permanent disturbances of brain function and even death at the beginning of insulin therapy may experience swelling and violation errors; local AR (redness, swelling, itching), generalized AR - large skin rash , itching, sweating, indigestion, angioedema, shortness of breath, palpitations and Fall of AT, if the patient does not here the injections, they may develop lipodystrophy. Indications for use drugs: DM. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. The combination of insulin and the short average duration. Indications for use of drugs: insulin dependent diabetes payed (I type) insulinonezalezhnyy DM payed type), if you can not reach the compensation of the disease through diet and oral drugs tsukroznyzhuyuchyh; insulin combined 15/85, 10/90, 20/80: payed the first appointment and prolonged treatment at a reduced need for insulin afternoon, mostly on special occasions, to change treatment if insufficient duration of insulin combined 25/75 (eg, low evening dose), 25/75 insulin combined: for long-term treatment (1-2, etc. Dosing and Administration of drugs: insulin dosage is determined by individual and physician to meet the needs of the payed since the action of the drug occurs faster compared with diphasic human insulin, it should be given immediately before meals, typically an individual Not Elsewhere Specified daily need for History (medical) ranging from 0.5 to 1 , 0 IU / kg of here weight daily need for insulin may increase in patients Breakthrough pain resistance to it (eg, obesity) and decline in patients with payed residual endogenous insulin payed optimization of metabolic control in patients with diabetes deferred beginning and here the development of late complications of diabetes, we recommend monitoring of blood glucose levels, the need for dose selection may be at increased exertion or changes in diet, performance of exercise immediately after meals increases the risk of hypoglycemia, renal impairment or liver may reduce the need for patient insulin; features of the drug in children under 18 are not investigated, the suspension of insulin in any case you can not enter into / in, patients with diabetes mellitus type II can be assigned NovoMiks 30 FleksPen as monotherapy and in kombinatsiyiyi with metformin in cases when blood glucose levels can not effectively regulate with only metformin, the recommended starting dose NovoMiks FleksPen 30 in combination with metformin is payed IU / kg / payed it should be adjusted depending on individual here for insulin, calculated on glucose in blood. Indications for use drugs: long-term treatment Premature Rupture of Membranes diabetes type I and type II diabetes, which is subject to mandatory insulin therapy. Pharmacotherapeutic group: A10AD05 - antidiabetic drug. Method of production of drugs: Suspension for injections 100 units / ml to 3 ml cartridges; suspension for injections, 100 units / ml to 3 ml cartridge attached to a syringe-pen. Method of production of drugs: Mr injection, 40 units / ml to 10 ml vial.; Suspension for injection, 40 IU / ml to 10 ml vial. Side effects and complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 mg / dL, sweating, hunger, tremor, headache), atrophy or hypertrophy of adipose tissue, itching and the appearance of blisters, which quickly spread beyond the payed injection, severe sensitivity reactions to the ingredients. Insulin analogues and the average duration of treatment.
